منابع مشابه
[Recent progress of KSR-a MAPK scaffold of the Ras pathway.].
Kinase Suppressor of Ras (KSR) is an intriguing component of the Ras pathway that was first identified by genetic studies performed in Drosophila melanogaster and Caenorhabditis elegans. In both organisms, inactivating mutations in KSR suppress the phenotypic effects induced by activated Ras. These findings together with the fact that KSR contains many structural features characteristic of a pr...
متن کاملKSR: A novel player in the RAS pathway
Over the past 5 years or so, developmental geneticists studying the nematode and the fruit fly have provided many new insights into the signaling pathways linking cell surface receptor tyrosine kinases with nuclear transcription factors. A central component in this information transfer mechanism is the RAS protein, a low molecular weight GTP-binding protein that is a proto-oncogene product in m...
متن کاملKinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo.
While scaffold proteins are thought to be key components of signaling pathways, their exact function is unknown. By preassembling multiple components of signaling cascades, scaffolds are predicted to influence the efficiency and/or specificity of signaling events. Here we analyze a potential scaffold of the Ras/mitogen-activated protein kinase (MAPK) pathway, kinase suppressor of Ras (KSR), by ...
متن کاملCAPRI regulates Ca2+-dependent inactivation of the Ras-MAPK pathway
Ca(2+) is a universal second messenger that is critical for cell growth and is intimately associated with many Ras-dependent cellular processes such as proliferation and differentiation. Ras is a small GTP binding protein that operates as a molecular switch regulating the control of gene expression, cell growth, and differentiation through a pathway from receptors to mitogen-activated protein k...
متن کاملKSR, a novel protein kinase required for RAS signal transduction
We have identified and characterized two genes in Drosophila whose products are required for activated RAS to signal with normal efficiency, but do not appear to effect signaling by activated RAF. One encodes the beta subunit of type I geranylgeranyl transferase, a prenylation enzyme essential for targeting RAS to the plasma membrane. The other encodes a protein kinase that we have named kinase...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2001
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.114.9.1609